Our recent article on system science in IEEE Computer generated an interesting email from Peter Saffrey, who pointed me at the Beacon project, which aims to "build a model of the human liver by composing models of biological entities down to the level of cells."
The project has produced several articles. I've just read one so far, "Computational Challenges of Systems Biology," by Anthony Finkelstein*, Peter Saffrey, and others, which provides a nice introduction to the field, written by computer scientists (and one biologist) for computer scientists.
*I remember Anthony from my time at Imperial College, when he impressed me with (among other things) his aphorism that "inheritance turns all programming into maintenance--which programmers are particularly bad at."
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